EL406
EL406
Washer Dispenser
The EL406 Combination Washer Dispenser offers fast, full plate washing along with three reagent dispensers in one, compact instrument. Its multiple capabilities include washing and dispensing for standard assays, plus biomagnetic separation and vacuum filtration protocols. The Dual-Action™ manifold optimizes washing for loosely adherent cell monolayers, while the patented Ultrasonic Advantage™ helps prevent blockages in the manifold tubes before washing, to reduce assay failure. Syringe pump and peristaltic pump dispensers each offer unique advantages, and the EL406 offers both, along with superior plate washing, on a single platform – making the EL406 a workhorse for your laboratory.
- Combines fast microplate washing with 3 reagent dispensers in 1 compact instrument
- 96-, 384- and 1536-well plate compatible
- Gentle processing for cell-based assays
- Bead washing: magnetic and polystyrene
- Easy maintenance with Ultrasonic Advantage™
APPLICATIONS
Applications for the EL406 Washer Dispenser run from simple dispense operations to full-scale automation of liquid handling steps in preparation for downstream processes. Here are a few important applications of the EL406.
- ELISA automation
- Bead washing
- Cell washing /media exchange
- Bulk reagent dispensing
- Cell seeding
Melamine ELISA: wash process by EL406
Post-EL406 media exchange validation, spheroids and cultured cells.
FEATURES
Washing and multiple reagent dispensing
There’s no need for multiple instruments when you have an EL406 in the lab! The EL406 is microplate washer with peristaltic and syringe pump modules available to make it into an efficient multi-tasking system. For benchtop use or integrated into automated systems, the EL406 does the work of multiple instruments.
96-, 384- and 1536-well plate compatible
BioTek’s Dual-Action™ manifold quickly washes 96- and 384-well plates. For 1536 washing, unique aspirate and dispense manifolds rapidly dispense and aspirate across the plate. Wash speeds for the three plate types range from 13 seconds to 36 seconds, keeping all your processes efficient.
Gentle processing for cell-based assays
Cell-based assays can be challenging to wash – too often, cell monolayers are disrupted by vigorous dispensing or overly intense aspiration. The EL406 Dual-Action manifold and plate carrier have x-y-z adjustments, and flow rates are fully adjustable – to optimize parameters for even the most sensitive assays. Angled dispense tubes direct fluid flow to the well sides, further minimizing disruption.
Bead washing: magnetic and polystyrene
Easy maintenance with Ultrasonic Advantage™
EL406 has a number of automated system maintenance features, including. BioTek’s Ultrasonic Advantage™. The dispense and aspirate tubes are immersed into the built-in ultrasonic bath in the priming trough while the automate cleaning program runs, dislodging and aspirating away salt crystal and protein buildup in the tubes.
GENERAL
| Microplate types | 96-, 384- and 1536-well Low profile and standard height Solid and filter bottom (option) |
| Onboard software | Create, edit or run multiple protocols |
| Software (computer control) | LHC2 Software LHC2 Secure for 21 CFR Part 11 compliance (option) SiLA Compliant driver (option) |
| Separation | Biomagnetic separation, vacuum filtration (optional) |
| Shaking | Programmable up to 60 minutes Slow, medium, fast or variable |
| Soaking | Programmable up to 60 minutes |
| Ultrasonic Advantage™ | Standard on most configurations |
| Automation | BioStack and 3rd party automation compatible BioSpa 8 Automated Incubator compatible |
WASHING
| Manifold types | 96-well washing: 96-tube manifold – straight dispense tubes 96- and 384-well washing: 96-tube Dual-Action manifold – 20° angled dispense tubes 384-well washing (fast): 192-tube Dual-Action manifold – 7° angled dispense tubes 1536-well washing: Two 32-tube dispense manifolds – 7° angled dispense tubes |
| Volume range | 3 – 3,000 µL/well in 1 µL increments |
| Wash cycles | 1 – 250 |
| Buffer/reagent selection | Auto switching module for up to 4 buffers (option) |
| Supply bottle | 4 L or 10 L (optional) |
| Dispense accuracy | +3% |
| Dispense precision | <3% CV (model dependent) |
| Residual volume | <2 µL/well |
| Wash speed | 96 wells, 300 µL/well, 96-tube manifold: 13 seconds 384 wells, 100 µL/well, 192-tube manifold: 17 seconds 1536 wells, 10 µL/wells, two 32-tube manifolds: 36 seconds |
| Flow rates | High flow to low flow Optimized rates for cell assays |
| Sterilization | Chemical |
| Vacuum range for filtration | Selectable: 0 to -380 mmHg (final at 30s) Filtration time: 5 – 999 seconds |
DISPENSING – PERISTALTIC PUMP (MULTI-CHANNEL)
| Manifold types | 8-tip (1 x 8) cassette with plastic, 316 SS tubes or sapphire jeweled 316 SS tubes |
| Fluid delivery | 1 peristaltic pump |
| Dispense speed | 96 wells, 10 µL /well: 8 seconds 384 wells, 5 µL /well: 12 seconds 1536 wells, 1 µL /well: 27 seconds |
| Volume range | 500 nL – 3,000 µL/well, selectable in 1 µL increments |
| Flow rates | User programmable rates from high to low Optimized rates for cell assays |
| Dispense performance | 1 µL cassette: Recommended Volume Range: 1 – 50 µL Dispense Accuracy: +5% at 1 µL Dispense Precision: <5% CV at 1 µL <10% CV at 500 nL Minimum Prime Volume: 1.20 mL 5 µL cassette: Recommended Volume Range: 5 – 2,500 µL Dispense Accuracy: +2.0% at 5 µL Dispense Precision: <2.5% CV at 5 µL Minimum Prime Volume: 4.23 mL 10 µL cassette: Recommended Volume Range: 10 – 3,000 µL Dispense Accuracy: +2.0% at 10 µL Dispense Precision: <2.0% CV at 10 µL Minimum Prime Volume: 7.36 mL |
| Recommended cassette replacement interval | 1 µL Cassette: 1,000 384-well microplates at 5 µL well 5 µL Cassette: 1,000 96-well microplates at 50 µL well 10 µL Cassette: 1,000 96-well microplates at 100 µL well |
| Sterilization | Autoclave, chemical |
DISPENSING – SYRINGE PUMP
| Manifold types | 96-well dispensing: One 16-tube (2 x 8) manifold – 316 SS tubes 96-/384-well dispensing: Two 16-tube (1 x 16) manifolds – 316 SS tubes 1536-well dispensing: Two 32-tube (1 x 32) manifolds – sapphire jeweled 316 SS or 316 stainless steel tubes |
| Fluid delivery | Two positive displacement syringe drives |
| Dispense speed | 20 µL /well, 96 wells, 1 x 16 tubes: 5.25 seconds 20 µL /well, 384 wells, 1 x 16 tubes: 14 seconds 3 µL /well 1536 wells, 2 x 32 tubes: 7 seconds |
| Volume range | 3 – 3,000 µL/well, selectable in 1 µL increments Minimum Prime Volume: 12 mL |
| Flow rates | User programmable rates from high to low |
| Dispense accuracy | +1 µL at 5 µL +1 µL at 20 µL +1% at 100 µL |
| Dispense precision | <5% CV at 5 µL <2.5% CV at 20 µL <1% CV at 100 µL |
| Supply bottle | 1 L or 2 L |
| Sterilization | Chemical, autoclavable option |
PHYSICAL CHARACTERISTICS
| Power | 100 – 240 Volts AC. 50/60 Hz |
| Dimensions | 16.5″ W x 18″ D x 12.5″ H (42 x 46 x 32 cm) |
| Weight | 32 lbs (14.5 kg) |
REGULATORY
| Regulatory | CE and TUV marked. ROHS compliant. In Vitro Diagnostic use models are available. |
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Part #
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1536-/ 384-/ 96-well | 1536-/ 384-well | 1536-well | 384-/ 96-well | 384-well | 96-well | 3 reagent disp. | 2 reagent disp. | 1 reagent disp. |
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406PSUB3SB
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406PSUB3LB
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406PSUB1SB
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406PSUB1LB
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406PSUB2SB
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406PSUB2LB
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406PSU0SB
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406PSU0LB
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406SNA0LB
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406PSUB3
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406PSUB1
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406PUB3
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406PUB1
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406PSUB2
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406PUB2
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406PSNA4
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406SNA4
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406P4
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| EL406™ 1536-/384-/96-well Microplate Washer Dispenser Configurations | ||
|---|---|---|
| Feature | Design | |
| P | 1-Reagent Dispense Module – 1 Peristaltic Pump |
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| S | 2-Reagent Dispense Module – 2 Syringe Pumps |
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| SNA | 2-Reagent Dispense Module – 2 Syringe Pumps |
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| U | Wash Module – Ultrasonic Advantage™ | |
| B | Wash Module – Automatic 4-Buffer Switching | |
| 1 | Wash Module – 384-/96-well microplate washing |
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| 2 | Wash Module – faster 384-well microplate washing |
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| 3 | Wash Module – 384-/96-well microplate washing |
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| 4 | Wash Module – 96-well microplate washing |
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| SB | Wash Module – 1536-well microplate washing and dispensing |
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| LB | Wash Module – 1536-well microplate washing and dispensing |
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